Submit Manuscript  

Article Details


Computational Outlook of Marine Compounds as Anti-Cancer Representatives Targeting BCL-2 and Survivin

[ Vol. 15 , Issue. 3 ]

Author(s):

Eram Shakeel, Rajnish Kumar, Neha Sharma, Salman Akhtar, Mohd. Kalim Ahmad Khan, Mohtashim Lohani and Mohd. Haris Siddiqui*   Pages 265 - 276 ( 12 )

Abstract:


Introduction: The regulation of apoptosis via compounds originated from marine organisms signifies a new wave in the field of drug discovery. Marine organisms produce potent compounds as they hold the phenomenal diversity in chemical structures. The main focus of drug development is anticancer therapy.

Methods: Expertise on manifold activities of compounds helps in the discovery of their derivatives for preclinical and clinical experiment that promotes improved activity of compounds for cancer patients.

Results: These marine derived compounds stimulate apoptosis in cancer cells by targeting Bcl-2 and Survivin, highlighting the fact that instantaneous targeting of these proteins by novel derivatives results in efficacious and selective killing of cancer cells.

Conclusion: Our study reports the identification of Aplysin and Haterumaimide J as Bcl-2 inhibitors and Cortistatin A as an inhibitor of survivin protein, from a sequential virtual screening approach.

Keywords:

Marine, Aplysin, Haterumaimide J, Cortistatin A, Bcl-2, surviving and molecular docking.

Affiliation:

Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow-226026, Uttar Pradesh, Amity Institute of Biotechnology, Amity University Uttar Pradesh, Lucknow-226028, Uttar Pradesh, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow-226026, Uttar Pradesh, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow-226026, Uttar Pradesh, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow-226026, Uttar Pradesh, Department of EMS, College of Applied Medical Sciences, University of Jazan, Jazan, Advanced Centre for Bioengineering and Bioinformatics (ACBB), Integral Information and Research Centre (IIRC), Integral University, Lucknow-226026, Uttar Pradesh

Graphical Abstract:



Read Full-Text article