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Design and Molecular Docking Studies of Some 2, 3 DI-Substituted Quinazolin-4-One Analogues Against Staphylococcus Aureus UDG

Author(s):

Amrute Bhavesh B.*, Amrutkar Rakesh D. and Tambe Santosh R.   Pages 1 - 5 ( 5 )

Abstract:


Background: In this present investigation, some 2, 3 disubstituted-quinazolin-4-one derivatives are designed and docked against chain A and chain B of (3WDF) receptor.

Methods: The heterocyclic fused rings quinazolinone have drawn a great attention owing to their expanded applications in the field of pharmaceutical chemistry. The diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit a broad spectrum of biological activities.

Results and Conclusion: The results designate that the quinazolinone ring forms hydrophobic and hydrogen bond contacts with ASN 127 A, ALA 126 A, and SER 83 B, SER 183 B amino acid residue.

Keywords:

Docking, Dock score, Conformer, Protein, Ligand, Quinazolinone

Affiliation:

Department of Pharmaceutical Chemistry, M.G.V`s Pharmacy College, Nashik, Maharashtra, Department of Pharmaceutical Chemistry M.G.V`s Samajshri Prashantdada Hiray College of Pharmacy, Malegaon, Nashik, Maharashtra, Department of Pharmaceutical Chemistry M.G.V`s Samajshri Prashantdada Hiray College of Pharmacy, Malegaon, Nashik, Maharashtra



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