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Synthesis and Anti-mycobacterium Study on Halo-substituted 2-aryl oxyacetohydrazones

Author(s):

Vijay J. Desale, Suraj N. Mali, Hemchandra K. Chaudhari, Maya C. Mali, Bapu R. Thorat* and Ramesh S. Yamgar   Pages 1 - 11 ( 11 )

Abstract:


Background: The treatment of multiple-drug-resistant tuberculosis (MDR-TB) with currently available marketed drugs is still remains a global health concern. The cases of resistant tuberculosis patients are increasing day by day.

Objective: There is a need to develop shorter, simpler and tolerable drug regimens.

Method: In present study, we have synthesized various halo-substituted 2-aryloxyacetohydrazones via series of reactions from halo-substituted phenols. All compounds were characterized by using various spectroscopic methods such as NMR, FT-IR, UV spectroscopy, etc.

Results: All the synthesized hydrazones were showed theoretically good interactions with enzyme enoyl reductase (pdb id: 4tzk). All the synthesized compounds (5a-5o) showed moderate to good activity (3.125-100 µg/mL) against Mycobacteria tuberculosis, H37RV strain.

Conclusion: Our results would definitely pave the new way towards development of more effective Anti-TB agents in future.

Keywords:

2-aryloxyacetohydrazones, Hydrazones, Anti-TB activity, Molecular Docking, Mycobacteria tuberculosis

Affiliation:

Department of Chemistry, N.B. Mehta Science College, Bordi, Dist. Palghar-401701, Maharashtra, cDepartment of Pharmaceutical Sciences, Institute of Chemical Technology, Matunga, Mumbai 400019, cDepartment of Pharmaceutical Sciences, Institute of Chemical Technology, Matunga, Mumbai 400019, cDepartment of Pharmaceutical Sciences, Institute of Chemical Technology, Matunga, Mumbai 400019, P.G. and Research Centre, Department of Chemistry, Government of Maharashtra’s Ismail Yusuf College, Jogeshwari, Mumbai-400060, Department of Chemistry, Patkar-Varde College of Arts, Science and Commerce, Goregaon (W), Mumbai 400 062



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